| Pair Name | All-trans retinoic acid, Cisplatin | ||
| Phytochemical Name | All-trans retinoic acid (PubChem CID: 444795 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | All-trans retinoic acid, Cisplatin | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Activity | ALDH1A1 | hsa216 |
| Up-regulation | Expression | SOX2 | hsa6657 | |
| Up-regulation | Expression | RARβ | KEGG ID N.A. | |
| In Vitro Model | NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 |
| NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 | |
| SK-MES-1 | Lung squamous cell carcinoma | Homo sapiens (Human) | CVCL_0630 | |
| NCI-H460 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0459 | |
| Result | These data support the concept of exploiting the retinoic acid signalling cascade as a novel strategy in targeting subsets of CSCs in cisplatin resistant lung tumours. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin. Transl Oncol. 2021 Apr;14(4):101025. doi: 10.1016/j.tranon.2021.101025. | Click |
